How to Talk to Your Oncologist About Clinical Trials

Bringing up clinical trials with your oncologist can feel intimidating. Here's how to have a productive conversation that gets you the information you need.

Before Your Appointment

1. Gather Your Information

• Know your diagnosis, stage, and any genetic mutations identified
• List your previous treatments and how you responded
• Research potential trials (use ClinicalMatch.ai to find matches)
• Print out 2-3 trial summaries to bring to your appointment

2. Prepare Questions

• "Are there any clinical trials you would recommend for my situation?"
• "What are the potential benefits and risks of this trial compared to standard treatment?"
• "Am I likely to be eligible based on my medical history?"
• "Would participating affect my current treatment plan?"

During the Conversation

Be direct: "I've been researching clinical trials and found some that might fit my profile. Can we discuss whether any of these would be appropriate for me?"

Listen actively: Your oncologist may have insights about trials you haven't found, or reasons why certain trials might not be a good fit.

Take notes: Bring someone with you or record the conversation (with permission) so you don't miss important details.

If Your Doctor Seems Hesitant

Some doctors are cautious about trials. If you encounter resistance:

• Ask specifically why they don't recommend a particular trial
• Request a referral to a larger cancer center for a second opinion
• Contact the trial site directly—they can often help determine eligibility

Remember

You are your own best advocate. Asking about clinical trials is a normal part of exploring all your treatment options.